Wound Healing and Antioxidant Evaluations of Alginate from Sargassum ilicifolium and Mangosteen Rind Combination Extracts on Diabetic Mice Model

A diabetic foot ulcer is an open wound that can become sore and frequently occurs in patients. Alginate has the ability to form a hydrophilic gel when contact with surface Xanthones are main compounds of mangosteen rind have antibacterial anti-inflammatory properties. The purpose this research was evaluate healing antioxidants assay combination alginate from S. ilicifolium extracts on mice model. characterization carried out by size exclusion chromatography multiple angle laser light scattering (SEC-MALLS) thermogravimetric analysis (TGA). M/G ratio calculated using proton nuclear magnetic resonance (1H NMR). antioxidant activity determined DPPH method. observed parameters were width, number neutrophils, macrophages, fibrocytes, fibroblasts, collagen densities. 36 male divided into 12 groups including non-diabetic control (NC), diabetes (DA), alginate–mangosteen (DAM), (DC) three different histopathology test skin tissue. treatment for 14 days evaluated Days 3, 7, 14. SEC-MALLS results showed molecular weight dispersity index (Ð) 2.77 × 104 Dalton 1.73, respectively. 0.77 described as single-stage decomposition based TGA. Alginate, extract, their weak, medium, strong antioxidant, DA DAM decrease width increase macrophages. neutrophils decreased while percentage densities increased all considered groups.